The MegaNatural® Difference

The MegaNatural® Difference

MegaNatural® grape seed extracts come from 100% California-grown grapes, traceable to the fields in which they were grown. This farm-to-finish production method ensures that you’re getting a premium product.

  • Free of common allergens and other adulterants, suitable for vegans and non-GMO

  • Water is the only solvent used. Ever.

  • FDA No-Objection GRAS (Generally Recognized as Safe)


We invest in original research

Polyphenolics has invested heavily in original research at both the laboratory and clinical levels. Original research is important because multiple factors – from the grape varietals chosen to the time of harvest and the extraction technique – can influence the product being tested. The only way to know if one of our condition-specific extracts is biologically effective is to test the specific composition of that extract.


We’re consistent

The consistency of every batch of MegaNatural® grape seed extracts is verified through specialized HPLC testing. This consistency guarantees consistent results in your supplement.

See our farm to finish manufacturing process

MegaNatural® grape seed extracts come from 100% California grown grapes traceable to the fields they were grown in. We’re GMO free cultivated using traditional methods, 100% natural, 100% grapes. We’re health conscious with a conscience.

Frequently Asked Questions

What is MegaNatural® BP?

MegaNatural®-BP is a patented grape seed extract shown to maintain blood pressure in human clinical trials conducted at the University of California at Davis Medical School. The product is made in California from a special seed blend entirely from unfermented red and varietal white wine grape seeds. The Polyphenols are extracted from grape seeds using hot water. The extract is then purified, concentrated and spray-dried into powder.

Is MegaNatural® BP safe?

MegaNatural®-BP is extracted from grapes using hot water. It has received GRAS status from the FDA, meaning the FDA considers it safe.

Are there any interactions with MegaNatural® BP?

There are no known interactions with MegaNatural®-BP, but check with your physician first.

Is MegaNatural® BP expensive?

On average, products containing MegaNatural®-BP cost less than $0.50 per day. Click here for a list of products that contain MegaNatural®-BP.

What are polyphenols?

Polyphenols are the most abundant group of plant phenolic compounds, known to provide much of the flavor, color, and taste to fruits, vegetables, seeds, and other parts of the plants. As dietary sources of biologically active compounds they prove to be valuable for health. They have been linked to reduce the risk of cariovascular disease, cancer, and other degenerative diseases. Commercially available grape seed and skin extracts are a rich source of these polyphenols. The various health benefits of polyphenols have been associated with their antioxidant, antibacterial, anti-inflammatory, and anti-allergenic properties.

How are the seeds stored prior to extraction?

After the seeds are separated from the skins and stems, they are dried to less than 8% moisture and stored in a cool, dry location until processed.

What is ORAC and how is it done?

ORAC stands for Oxygen Radical Absorbance Capacity. In this assay the ability of a substance to subdue oxygen free radicals in vitro or “total antioxidant capacity” is determined. The method is spectrofluorometric, performed by an outside lab (automated), and it is based on the time-dependent decrease in the fluorescence of the beta-PE indicator protein with the following parameters:

– Free-radical generating system: AAPH
– Sensitive target of the free radical attack: B- or R-PE
– Quantification: area under the curve (combines both inhibition percentage and the length of inhibition time of free radical action by an antioxidant into a single quantity)
Trolox (water-soluble analog of vitamin E) is used as a standard. This method is more common in the U.S. than in Europe and more customers are requesting this data.

We had samples analyzed for ORAC values by Brunswick Laboratories (Wareham, MA). They have a fairly detailed web site that explains ORAC as well.

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