Letter from the President
I’m unsure why May is such a popular month for health-awareness issues. Perhaps it’s because people feel more compelled to take better care of themselves when they’re outdoors enjoying the gorgeous spring weather.
Whatever the reason, Polyphenolics strongly supports the additional focus on such important concerns as high blood pressure, stroke, fitness and women’s health. And this public education is working. Americans are becoming savvier about proactively supporting their wellness. Preserving good health is the best anti-aging strategy. In this month’s communication, we’ve compiled information on each of these topics.
James A. Kennedy, Ph.D.
National Women’s Health Week
Mother’s Day, which was celebrated May 14, also kicked-started the beginning of National Women’s Health Week.
In honor of all the women in your life, we’re recommending this book which provides advice for taking care of their hearts: “Saving Women’s Hearts – How You Can Prevent and Reverse Heart Disease With Natural and Conventional Strategies” by Martha Gulati, MD, MS, FACC, FAHA and Sherry Torkos BSc Phm.
Heart disease is the number one killer of women in North America. Martha Gulati, a cardiologist, and Sherry Torkos, a pharmacist and health author, carefully selected several dietary supplements to recommend to save women’s hearts. MegaNatural®-BP is discussed on pages 144 and 145 of their book as an effective way to maintain blood pressure.13
“MegaNatural BP has shown promise for the management of high blood pressure. Preliminary research shows that this extract can lower both systolic and diastolic blood pressure in those with elevated blood pressure without any adverse effects. The recommended dosage is 150 to 300 mg daily.”
National High Blood Pressure Education Month
Healthy blood pressure is a key indicator of a healthy heart. It’s alarming that an estimated one in three U.S. adults (about 75 million people) have high blood pressure. Slightly more than half, about 54 percent, have it under control.1
What is blood pressure and why is it so important? With each heartbeat, blood is pumped into the arteries. Blood pressure measures the amount of force exerted against the walls of the arteries in response to the pumping action of the heart. The intensity of that force depends on the volume of blood being pumped and the flexibility of the arteries.2, 3
Like a balloon being filled with water, pressure rises when the arteries contain a large amount of blood. Similarly, when the arteries lose some of their natural balloon-like flexibility, they can no longer expand easily to accommodate increased blood flow, again causing an increase in pressure. Elevated blood pressure causes the arteries to become even stiffer, initiating and perpetuating a vicious cycle.2, 3
Blood pressure is measured in two numbers: the higher number represents systolic blood pressure (the force when the heart contracts); the lower number represents diastolic blood pressure (the force when the heart rests). Below 120 mmHg/80 mmHg is considered healthy.4
Healthy blood pressure allows the heart to pump blood at a relaxed pace. When arterial pressure rises, the heart must work harder to keep blood flowing. This isn’t a problem when the increased demand is occasional, such as during intense exercise. However, when the heart is forced to pump hard all the time, it puts tremendous stress on this important organ.2, 3
National Stroke Awareness Month
The National Stroke Association reports that stroke is the fifth leading cause of death and a leading cause of adult disability.6 Strokes happen when the blood supply is cut off from an area of the brain, depriving cells of oxygen. Strokes can result in loss of speech and mobility, as well as memory impairment.
Up to 80 percent of strokes can be prevented by managing such lifestyle risk factors such as diet and exercise, as well as medical risk factors. The number one cause of strokes is high blood pressure. People with high blood pressure have a 1.5 times higher stroke risk than those with optimal blood pressure.7
The Promise of MegaNatural®-BP
Fortunately, there is a natural way to help maintain blood pressure levels within a healthy range: polyphenols.* Naturally occurring in fruits, vegetables and red wine, polyphenols are a class of phytonutrients that have been scientifically demonstrated to support cardiovascular health.* One of the largest natural sources of polyphenols is grape seed extract.3
Manufactured exclusively by Polyphenolics, a division of Constellation Brands — the world’s leading premium wine company — MegaNatural®-BP is a patented grape seed extract with clinically shown benefits. In fact, three placebo controlled human clinical trials conducted by researchers at the Department of Preventative Cardiology, University of California Davis School of Medicine, have found that MegaNatural®-BP supports blood pressure within the normal range.*3, 8-11
No other grape seed extract can say the same, since MegaNatural®-BP has a patented unique structure and composition.12 (U.S. patent No. 7,767,235).
National Physical Fitness and Sports Month
Every May, The President’s Council on Fitness, Sports and Nutrition encourages Americans to #MoveInMay and become a healthier you.14
MegaNatural®-BP and MegaNatural®-Gold may be what you’re looking for to fill your sports nutrition gaps. In his white paper, MegaNatural® Grape Seed Extracts and their role in Sports Nutrition Polyphenolics President Jim Kennedy points out that when we breathe harder and our hearts beat faster, we expose our bodies to increased oxidative stress. This is caused by the production of damaging free radicals. Left unchecked, these free radicals can lead to cellular damage. MegaNatural® grape seed extracts are rich in antioxidants and mayreduce free radicals.15
MegaNatural® Gold grape seed extract and MegaNatural® BP grape seed extract offer very specific sports nutrition benefits. MegaNatural® Gold grape seed extract has been clinically shown to be an effective antioxidant, increases antioxidant activity in our blood plasma. Its antioxidant quality and quantity are superior to other sources. When MegaNatural® Gold is taken in combination with either Vitamin C or Vitamin E, the vitamin’s antioxidant capacity is doubled!15, 16
And here’s something athletes will want to know about MegaNatural® BP grape seed extract: Not only is it an effective antioxidant, but MegaNatural® BP has been clinically shown to help maintain healthy nitric oxide levels that are within the normal range.15 Many athletes actively seek sports nutrition supplements that promote nitric oxide benefits because this helps support healthy vasodilation and blood flow.8
Through our extensive research, and our ongoing commitment to farm-to-shelf purity and transparency, Polyphenolics is devoted to ensuring that MegaNatural®-BP and MegaNatural®-Gold are trusted ingredients in your wellness product formulations.
- Wright JR Jr, Williamson JD, Whelton PK, et al. A Randomized Trial of Intensive versus Standard Blood-Pressure Control. New Engl J Med. 2015; 373: 2103-16.
- Edirisinghe I, Burton-Freeman B, Tissa Kappagoda C. Mechanism of the endothelium-dependent relaxation evoked by a grape seed extract. Clin Sci. 2008; 114: 331-337.
- Sivaprakasapillai B, Edirisinghe I, Randolph J, Steinberg F, Kappagoda T. Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome. Metabolism. 2009; 58: 1743-1746.
- Robinson M, Lu B, Edirisinghe I, Kappagoda CT. Effect of grape seed extract on blood pressure subjects with pre-hypertension. J Pharm Nutri Sci. 2012; 155-159.
- Park E, Edirisinghe I, Choy YY, Waterhouse A, Burton-Freeman B. Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a randomised, double-blinded, two-arm, parallel, placebo-controlled trial. Brit J Nutr. 2016; 115: 226-38.
- Vinson JA, Proch J, Bose P. MegaNatural Gold Grapeseed Extract: In Vitro Antioxidant and In Vivo Human Supplementation Studies. J. Med. Food 2001; 4: 17-26.
*The material in this communication is intended to be of general information use and is not intended to constitute medical advice, probable diagnosis or recommended treatments.
**These claims have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.